e.g. metabolic pathway engineering
6-8 months for proof of principle for enzyme or protein of interest
Milestone based project(s) towards target specs
Screening for new enzymes
Intensive knowledge transfer preceeding commercial production in partner facility
The metabolic pathway for fungal production of different bio-chemicals was developed and patented by Dutch DNA. The fermentation technology for the production of Itaconic Acid is currently being tested at pilot scale. After industrial scale is established in 2019 / 2020 the first release of this proprietary technology is ready to be licensed out.
Itaconic Acis id used in chemical Industry. The building block can be used for the production of thermoplastic polymers and acrylate latexes.
If you have other needs than Itaconic Acid don’t hesitate to contact us. We have more than a decade of experience in metabolic pathway engineering.
If you have unmet needs for enzymes we suggest you contact us. We possess a collection of production strains to be licensed out. Off course we will jointly select the most suitable out of this collection and transform the choosen so that it fulfills your specific needs for enzymes (enzyme-cocktails). If you are searching for a specific enzyme activity we suggest you contact us. We own a biological screen enabling the search for enzyme activity. The collateral benefit of our screening method is that, if activity is found, there is a possitive answer to the question of whether found enzyme(s) are producable. If you need a research license for your own work, we suggest you contact us.
Are you in search for (animal or plant) proteins to be produced via fermentation please reach out. Our strains, with proven double digit gr/l production titers are ready to go.
This project is focussing on toxicity and transport for fungal production of industrial compounds. Using an integrative approach focused on the simultaneous optimization of host and biosynthetic pathway several aspects of the production and secretion of itaconic Acid have been addressed to improve the production rates to levels suitable for commercialization of the fungal production process. The insights obtained will open up new opportunities in the framework of the bio-based economy. Please learn more on our consortium partners.
Fungal Chitosans from fermentation Mycelia for plant Biostimulants. By targeting the cell wall biosynthetic machinery of Aspergillus Niger, using strain engineering both fungal fermentation performance and chitin content of myceliall biomass is increased. The latter allowing improved extraction of chitin oligomers. The fungal chitin derivatives are explored as alternative plant biostimulants. The main partner is University of Munster. If you want to know more on other consortiumpartners please click here.
Enzymes for 2nd generation sugars.
A new process for the production of second generation sugars is developed up to pilotscale. The consortium endeavors to combine the organosolv process with enzymatic pretreatment of woody substrate. Dutch DNA together with Leipzig University developed new Penicillium verruculosum strains producing improved enzyme cocktails.
Novel approaches to develop filamentous micro-organisms for enzyme production.
The consortium developed new enzymes and cell factories that can upgrade current enzyme cocktails for the complete degradation of biomass. Dutch DNA focused on the commonly used filamentous fungal cell factory, Aspergillus Niger.
In this project we adapt our proprietary IA production technology to ferment on second generation feedstocks of two consortium partners. The University of Delft focusses on down stream processing and economic evaluation of the complete valuechain. For more information please click here.
Next generation sequencing equipment analyses billions of nucleotides per day. The portable nanopore technology is in its infancy, but promisses to change genomics drastically in few years time.
In Porelab researchers, students and SME are working together to work out the full potential of this technology. They explore all possible applications.