e.g. metabolic pathway engineering
6-8 months for proof of principle for enzyme or protein of interest
Milestone based project(s) towards target specs
Screening for new enzymes
Intensive knowledge transfer preceeding commercial production in partner facility
Tune functionality of proteins to replace animal proteins with food structuring abilities.
If you have unmet needs for enzymes DDNA is your partner; both in enzyme discorvery / screening as well as production of enzymes.
We own a biological screen enabling the search for enzyme activity. The collateral benefit of our screening method is that, if activity is found, there is also a possitive answer to the question of whether the found enzyme(s) are producable. The latter is not obvious in biology. It has happened several times that clients came to us after expensive years in their labs with an new enzyme (cocktail) only to discover that it can’t be produced. The screening approach we apply prevents the scenario of substantial sunk costs.
Next to enzyme discovery / screening in which we act as CRO we provide you with tailored production technology to be licensed out.
Since 2018 the majority of our own proprietary technology developments focus on the affordable production of functional proteins for food and health applications. In time due we will produce and commercialize these proteins together with strategic partners.
If you want to learn more, just give us a call.
The metabolic pathway for fungal production of different bio-chemicals was developed and patented by Dutch DNA.
The fermentation technology for the production of Itaconic Acid is currently being tested at pilot scale. After industrial scale is established in 2019 / 2020 the first release of this proprietary technology is ready to be licensed out.
Itaconic Acis id used in chemical Industry. The building block can be used for the production of thermoplastic polymers and acrylate latexes.
If you have other needs than Itaconic Acid don’t hesitate to contact us. We have more than a decade of experience in metabolic pathway engineering.
Current solutions for plastic waste management are less than optimal, being in most part incineration and landfilling. Back to Mono (B2M) takes the first steps on the way to sustainable plastic recycling. By using fungal enzymes, plastic is depolymerized and converted to re-usable monomers allowing a virtually indefinite plastic recycling. By screening a collection of filamentous fungi, we aim to identify new enzymes that process plastic polymers and return the original chemical building blocks. The ultimate objective of the project is an industrial process in which those building blocks will be re-used for new products.
Fungal Chitosans from fermentation Mycelia for plant Biostimulants. By targeting the cell wall biosynthetic machinery of Aspergillus Niger, using strain engineering both fungal fermentation performance and chitin content of myceliall biomass is increased. The latter allowing improved extraction of chitin oligomers. The fungal chitin derivatives are explored as alternative plant biostimulants. The main partner is University of Munster. If you want to know more on other consortiumpartners please click here.
Enzymes for 2nd generation sugars.
A new process for the production of second generation sugars is developed up to pilotscale. The consortium endeavors to combine the organosolv process with enzymatic pretreatment of woody substrate. Dutch DNA together with Leipzig University developed new Penicillium verruculosum strains producing improved enzyme cocktails.
Novel approaches to develop filamentous micro-organisms for enzyme production. The consortium developed new enzymes and cell factories that can upgrade current enzyme cocktails for the complete degradation of biomass. Dutch DNA focused on the commonly used filamentous fungal cell factory, Aspergillus Niger.
In this project we adapt our proprietary IA production technology to ferment on second generation feedstocks of two consortium partners. The University of Delft focusses on down stream processing and economic evaluation of the complete valuechain. For more information please click here.
Next generation sequencing equipment analyses billions of nucleotides per day. The portable nanopore technology is in its infancy, but promisses to change genomics drastically in few years time.
In Porelab researchers, students and SME are working together to work out the full potential of this technology. They explore all possible applications.