Developments on organic acid production

As a new addition to our research on metabolic pathway engineering, we have recently published the results of our research and collaborations in the framework of the ERA-IB TTRaFFIC project on Metabolic engineering and fermentation optimization improve itaconic acid production in Aspergillus niger.

In this paper we show how we have successfully improved our patented IA biosynthesis pathway by metabolic engineering of ATP-citrate lyase. Furthermore, we have improved the fermentation protocol, and combined with the improved pathway this has resulted in titers close to those required for commercial application of this technology. In addition to these results we have been able to show that the strains developed sofar are also able to produce high levels of itaconic acid on agricultural residues based feedstocks (research performed in the framework of the TKI-BBE project Veni Vidi Viride). Parties interested in this technology and the associated IP portfolio are invited to contact us (Cornelis.Mijnders@ddna-biotech.com).

Find us at the Mycologische dag KNMV

Dutch DNA Biotech delegation – Dr Ebru Alazi, Dr Sylvia Segers, Abeer Hossain and Prof Peter Punt – will join the Mycologische dag of the KNMV at Danone venue on Utrecht Science Park, November 30th.

Don’t miss the presentation of Abeer Hossain starting at 14:00 hours. Abeer is our lead scientist organic acids. He  presents the results of his research on Itaconic Acid degradation in Aspergillus Niger.

Art de Boo at the CLEAN TECH Forum

Our CEO, Art de Boo, will contribute to this years edition with a presentation on the future of biochemicals. It will be during the bio-based chemical innovation session on Tuesday, May 15, at 2:00pm – 2:45pm.

The Cleantech Forum Europe, now in its 14th edition, continues to be the place to create connections and to connect the dots across multiple industrial sectors. This year’s Cleantech Forum Europe will be held in Antwerp, home to Europe’s largest chemical hub and the world’s most tightly concentrated petrochemical hub, and also home to Europe’s second largest port and a key continental logistics hub.

2nd generation Itaconic Acid on it’s way

We are happy to announce that the Veni Vidi Veridi (VVV) collaborative project is granted.

In this project Dutch DNA works together with partners DSD, Viride SuStra and the TU Delft to make residual agricultural streams available for high-quality applications.

Next to project coordinator, Dutch DNA’s role within the VVV project is to deliver the biotechnology for robust and efficient fermentation of agricultural residual streams into Itaconic Acid (IA). Currently, IA production on 1G sugars by DDNA’s proprietary Aspergillus niger strains – based on a patented pathway – is at par with the industrial standard, Aspergillus terreus. Moreover, our strains efficiently ferment 2G sugars into IA, which is a feat that A. terreus is not able to do.

The ambition of the consortium is to produce IA in a sustainable and cost-effective manner by further developing proprietary technologies and set up a IA value chain.

The project will take two years and starts first of January 2018.